A southern writer named John Kennedy Toole wrote a comic novel about life in New Orleans called A Confederacy of Dunces. It was so relentlessly rejected by publishers that he killed himself. That was in 1969. His mother refused to give up on the book. She sent it out and got it back, rejected, over and over again. At last she won the patronage of Walker Percy, who got it accepted by the Louisiana State University Press, and in 1980 it won a Pulitzer Prize for fiction.